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Drug Information

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  • Common uses
  • How to take the medication
  • Common side effects
  • Precautions & interactions

How Ramucirumab Injection works, side effects, interactions and precautions.

Ramucirumab Injection

Ramucirumab Injection

(ra'' mue sir' ue mab)

Brand Name(s): , Cyramza®


IMPORTANT WARNING:

Ramucirumab injection may cause severe bleeding that can be life-threatening and even cause death. If you experience any of the following symptoms, call your doctor immediately: coughing up or vomiting blood or material that looks like coffee grounds, unusual bleeding or bruising, pink, red, or dark brown urine, red or tarry black bowel movements, lightheadedness, nosebleeds, other unusual bleeding or bruising. Your doctor may stop ramucirumab injection if you experience severe bleeding.

Ramucirumab may cause you to develop a hole in the wall of your stomach or intestine. This is a serious and possibly life-threatening condition. If you experience any of the following symptoms, call your doctor immediately: stomach pain, constipation, nausea, vomiting, shivering, or fever.

Ramucirumab may slow the healing of wounds, such as cuts made by a doctor during surgery. Tell your doctor if you have recently had surgery or if you plan to have surgery.

Talk to your doctor about the risks of using ramucirumab injection.

WHY is this medicine prescribed?

Ramucirumab injection is used alone and in combination with another chemotherapy medication to treat stomach cancer or cancer located in the area where the stomach meets the esophagus (the tube between the throat and stomach) when these conditions do not improve after treatment with other medications. Ramucirumab is also used in combination with another chemotherapy medication to treat a certain type of non-small cell lung cancer (NSCLC) that has spread to other parts of the body in people who have already been treated with other chemotherapy medications and have not improved or worsened. Ramucirumab is also used in combination with other chemotherapy medications to treat cancer of the colon (large intestine) or rectum that has spread to other parts of the body in people that have already been treated with other chemotherapy medications and have not improved or worsened. Ramucirumab is in a class of medications called monoclonal antibodies. It works by stopping the growth of cancer cells.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Ramucirumab injection comes as a liquid to be injected into a vein over 60 minutes by a doctor or nurse in a hospital or medical facility. For the treatment of stomach cancer or cancer of the colon or rectum, it is usually given once every 2 weeks. For the treatment of NSCLC, ramucirumab is usually given once every 3 weeks. The length of your treatment depends on how well your body responds to the medication and the side effects that you experience.

Your doctor may need to interrupt or stop your treatment if you experience certain side effects. Your doctor will give you other medications to prevent or treat certain side effects before you receive each dose of ramucirumab injection. Tell your doctor or nurse if you experience any of the following while you receive ramucirumab: uncontrollable shaking of a part of the body; back pain or spasms; chest pain and tightness; chills; flushing; shortness of breath; wheezing; pain, burning, numbness, pricking, or tingling in the hands or feet or on the skin; breathing difficulties; fast heartbeat.

What SPECIAL PRECAUTIONS should I follow?

Before receiving ramucirumab injection,

  • tell your doctor and pharmacist if you are allergic to ramucirumab or any other medications or any of the ingredients in ramucirumab injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had high blood pressure, a wound that has not healed, or thyroid, or liver disease.
  • you should know that ramucirumab may cause infertility in women (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant. Tell your doctor if you are pregnant or plan to become pregnant. You should use birth control to prevent pregnancy during your treatment and for at least 3 months after your final treatment. Talk to your doctor about birth control methods that will work for you. If you become pregnant during your treatment with ramucirumab injection, call your doctor immediately. Ramucirumab may harm the fetus.
  • tell your doctor if you are breastfeeding. You should not breastfeed during your treatment with ramucirumab.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Call your doctor right away if you are unable to keep an appointment to receive a dose of ramucirumab injection.

What SIDE EFFECTS can this medicine cause?

Ramucirumab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • sores in the mouth or throat

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • rash
  • sudden weakness of an arm or leg
  • drooping of one side of the face
  • difficulty speaking or understanding
  • crushing chest or shoulder pain
  • slow or difficult speech
  • chest pain
  • shortness of breath
  • headache
  • dizziness or faintness
  • seizures
  • confusion
  • change in vision or loss of vision
  • extreme tiredness
  • swelling of the face, eyes, stomach, hands, feet, ankles, or lower legs
  • unexplained weight gain
  • foamy urine
  • sore throat, fever, chills, ongoing cough and congestion, or other signs of infection

Ramucirumab injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ([WEB]) or by phone (1-800-332-1088).

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor our doctor will check your blood pressure and test your urine regularly during your treatment with ramucirumab.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.



This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS® Patient Medication Information™. © Copyright, 2018. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: November 15, 2018.

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